Ethical issues in randomised trials in surgery
نویسندگان
چکیده
منابع مشابه
Randomised placebo-controlled trials of surgery: ethical analysis and guidelines
Use of a placebo control in surgical trials is a divisive issue. We argue that, in principle, placebo controls for surgery are necessary in the same way as for medicine. However, there are important differences between these types of trial, which both increase justification and limit application of surgical studies. We propose that surgical randomised placebo-controlled trials are ethical if ce...
متن کاملScientific and ethical issues in equivalence trials.
ANY TESTING OF MEDICAL TREATMENTS IS AN EXERcise in comparison. In a typical clinical trial, 2 treatments are compared to determine which is better or if both are the same. Trials designed to address whether one treatment is better than the other may be called superiority trials, whereas those designed to show that 2 treatments are the same are called equivalence trials. However, the design of ...
متن کاملEthical issues in naturalistic versus controlled trials
Ethical core issues in research with human subjects are related to informed consent and risk-benefit assessment. This is valid for all types of studies. However, there has been much greater focus of ethical considerations on controlled clinical trials than on naturalistic trials, probably because the former are interventional in nature and may have unknown and perhaps severe somatic risks, wher...
متن کاملEthical issues in tuberculosis vaccine trials.
Bacille Calmette-Guérin (BCG) vaccines are widely used, even though estimates of efficacy have ranged from zero to 80%. BCG is a relatively safe vaccine, but it can cause disseminated infection, especially in immunocompromised hosts. Thus, the development of a more reliably efficacious and safer vaccine is important to the control of tuberculosis. The testing of any new vaccine in human populat...
متن کاملClinical trials in neonates: ethical issues.
If neonates are to receive the best possible treatment, they must be involved in clinical trials. However, doing such trials raises complicated ethical issues. These issues are not unique to neonatology but some are more common or acute than in other areas of medicine. In practice, two particular issues -- equipoise and informed consent -- arise as many different types of problem. The question ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Medical Ethics
سال: 2021
ISSN: 0974-8466,0975-5691
DOI: 10.20529/ijme.2020.099